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- Title
Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways.
- Authors
Aletrari, Mina-Olga; McKibbin, Craig; Williams, Helen; Pawar, Vidya; Pietroni, Paola; Lord, J Michael; Flitsch, Sabine L; Whitehead, Roger; Swanton, Eileithyia; High, Stephen; Spooner, Robert A
- Abstract
The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates. Toxins such as ricin and Shiga/Shiga-like toxins (SLTx) are endocytosed and trafficked to the ER. Their catalytic subunits are thought to utilise ERAD-like mechanisms to dislocate from the ER into the cytosol, where a proportion uncouples from the ERAD process, recovers a catalytic conformation and destroys their cellular targets. We therefore investigated ESI as a potential inhibitor of toxin dislocation.
- Publication
PloS one, 2011, Vol 6, Issue 7, pe22713
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0022713