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- Title
Establishing long-term efficacy in chronic disease: use of recursive partitioning and propensity score adjustment to estimate outcome in MS.
- Authors
Goodin, Douglas S; Jones, Jason; Li, David; Traboulsee, Anthony; Reder, Anthony T; Beckmann, Karola; Konieczny, Andreas; Knappertz, Volker; 16-Year Long-Term Follow-up Study Investigators
- Abstract
Establishing the long-term benefit of therapy in chronic diseases has been challenging. Long-term studies require non-randomized designs and, thus, are often confounded by biases. For example, although disease-modifying therapy in MS has a convincing benefit on several short-term outcome-measures in randomized trials, its impact on long-term function remains uncertain.
- Publication
PloS one, 2011, Vol 6, Issue 11, pe22444
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0022444