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- Title
Novel automated blood separations validate whole cell biomarkers.
- Authors
Burger, Douglas E; Wang, Limei; Ban, Liqin; Okubo, Yoshiaki; Kühtreiber, Willem M; Leichliter, Ashley K; Faustman, Denise L
- Abstract
Progress in clinical trials in infectious disease, autoimmunity, and cancer is stymied by a dearth of successful whole cell biomarkers for peripheral blood lymphocytes (PBLs). Successful biomarkers could help to track drug effects at early time points in clinical trials to prevent costly trial failures late in development. One major obstacle is the inaccuracy of Ficoll density centrifugation, the decades-old method of separating PBLs from the abundant red blood cells (RBCs) of fresh blood samples.
- Publication
PloS one, 2011, Vol 6, Issue 7, pe22430
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0022430