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- Title
Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide.
- Authors
Spijkers, Léon J A; van den Akker, Rob F P; Janssen, Ben J A; Debets, Jacques J; De Mey, Jo G R; Stroes, Erik S G; van den Born, Bert-Jan H; Wijesinghe, Dayanjan S; Chalfant, Charles E; MacAleese, Luke; Eijkel, Gert B; Heeren, Ron M A; Alewijnse, Astrid E; Peters, Stephan L M
- Abstract
Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. As sphingolipids have been implicated in both the regulation of vascular contractility and growth, we investigated whether sphingolipid biology is altered in hypertension and whether this is reflected in altered vascular function.
- Publication
PloS one, 2011, Vol 6, Issue 7, pe21817
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0021817