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- Title
Different requirement for Wnt/β-catenin signaling in limb regeneration of larval and adult Xenopus.
- Authors
Yokoyama, Hitoshi; Maruoka, Tamae; Ochi, Haruki; Aruga, Akio; Ohgo, Shiro; Ogino, Hajime; Tamura, Koji
- Abstract
In limb regeneration of amphibians, the early steps leading to blastema formation are critical for the success of regeneration, and the initiation of regeneration in an adult limb requires the presence of nerves. Xenopus laevis tadpoles can completely regenerate an amputated limb at the early limb bud stage, and the metamorphosed young adult also regenerates a limb by a nerve-dependent process that results in a spike-like structure. Blockage of Wnt/β-catenin signaling inhibits the initiation of tadpole limb regeneration, but it remains unclear whether limb regeneration in young adults also requires Wnt/β-catenin signaling.
- Publication
PloS one, 2011, Vol 6, Issue 7, pe21721
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0021721