We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.
- Authors
Han, Xianlin; Rozen, Steve; Boyle, Stephen H; Hellegers, Caroline; Cheng, Hua; Burke, James R; Welsh-Bohmer, Kathleen A; Doraiswamy, P Murali; Kaddurah-Daouk, Rima
- Abstract
The development of plasma biomarkers could facilitate early detection, risk assessment and therapeutic monitoring in Alzheimer's disease (AD). Alterations in ceramides and sphingomyelins have been postulated to play a role in amyloidogensis and inflammatory stress related neuronal apoptosis; however few studies have conducted a comprehensive analysis of the sphingolipidome in AD plasma using analytical platforms with accuracy, sensitivity and reproducibility.
- Publication
PloS one, 2011, Vol 6, Issue 7, pe21643
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0021643