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- Title
Absence of birth-weight lowering effect of ADCY5 and near CCNL, but association of impaired glucose-insulin homeostasis with ADCY5 in Asian Indians.
- Authors
Vasan, Senthil K; Neville, Matt J; Antonisamy, Belavendra; Samuel, Prasanna; Fall, Caroline H; Geethanjali, Finney S; Thomas, Nihal; Raghupathy, Palany; Brismar, Kerstin; Karpe, Fredrik
- Abstract
A feature of the Asian Indian phenotype is low birth weight with increased adult type 2 diabetes risk. Most populations show consistent associations between low birth weight and adult type 2 diabetes. Recently, two birth weight-lowering loci on chromosome 3 (near CCNL1 and ADCY5) were identified in a genome-wide association study, the latter of which is also a type 2 diabetes locus. We therefore tested the impact of these genetic variants on birth weight and adult glucose/insulin homeostasis in a large Indian birth cohort.
- Publication
PloS one, 2011, Vol 6, Issue 6, pe21331
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0021331