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- Title
Immunodominance of HIV-1 specific CD8+ T-cell responses is related to disease progression rate in vertically infected adolescents.
- Authors
Sharp, Elizabeth R; Willberg, Christian B; Kuebler, Peter J; Abadi, Jacob; Fennelly, Glenn J; Dobroszycki, Joanna; Wiznia, Andrew A; Rosenberg, Michael G; Nixon, Douglas F
- Abstract
HIV-1 vertically infected children in the USA are living into adolescence and beyond with the widespread use of antiretroviral drugs. These patients exhibit striking differences in the rate of HIV-1 disease progression which could provide insights into mechanisms of control. We hypothesized that differences in the pattern of immunodomination including breadth, magnitude and polyfunctionality of HIV-1 specific CD8+ T cell response could partially explain differences in progression rate.
- Publication
PloS one, 2011, Vol 6, Issue 7, pe21135
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0021135