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Title
Extended interferon-alpha therapy accelerates telomere length loss in human peripheral blood T lymphocytes.
Authors
O'Bryan, Joel M; Potts, James A; Bonkovsky, Herbert L; Mathew, Anuja; Rothman, Alan L; HALT-C Trial Group
Abstract
Type I interferons have pleiotropic effects on host cells, including inhibiting telomerase in lymphocytes and antiviral activity. We tested the hypothesis that long-term interferon treatment would result in significant reduction in average telomere length in peripheral blood T lymphocytes.