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- Title
Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression.
- Authors
Fomchenko, Elena I; Dougherty, Joseph D; Helmy, Karim Y; Katz, Amanda M; Pietras, Alexander; Brennan, Cameron; Huse, Jason T; Milosevic, Ana; Holland, Eric C
- Abstract
Gliomas are thought to form by clonal expansion from a single cell-of-origin, and progression-associated mutations to occur in its progeny cells. Glioma progression is associated with elevated growth factor signaling and loss of function of tumor suppressors Ink4a, Arf and Pten. Yet, gliomas are cellularly heterogeneous; they recruit and trap normal cells during infiltration.
- Publication
PloS one, 2011, Vol 6, Issue 7, pe20605
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0020605