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- Title
Designing nanoconjugates to effectively target pancreatic cancer cells in vitro and in vivo.
- Authors
Khan, Jameel Ahmad; Kudgus, Rachel A; Szabolcs, Annamaria; Dutta, Shamit; Wang, Enfeng; Cao, Sheng; Curran, Geoffry L; Shah, Vijay; Curley, Steven; Mukhopadhyay, Debabrata; Robertson, J David; Bhattacharya, Resham; Mukherjee, Priyabrata
- Abstract
Pancreatic cancer is the fourth leading cause of cancer related deaths in America. Monoclonal antibodies are a viable treatment option for inhibiting cancer growth. Tumor specific drug delivery could be achieved utilizing these monoclonal antibodies as targeting agents. This type of designer therapeutic is evolving and with the use of gold nanoparticles it is a promising approach to selectively deliver chemotherapeutics to malignant cells. Gold nanoparticles (GNPs) are showing extreme promise in current medicinal research. GNPs have been shown to non-invasively kill tumor cells by hyperthermia using radiofrequency. They have also been implemented as early detection agents due to their unique X-ray contrast properties; success was revealed with clear delineation of blood capillaries in a preclinical model by CT (computer tomography). The fundamental parameters for intelligent design of nanoconjugates are on the forefront. The goal of this study is to define the necessary design parameters to successfully target pancreatic cancer cells.
- Publication
PloS one, 2011, Vol 6, Issue 6, pe20347
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0020347