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- Title
High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells.
- Authors
Zhang, Yingze; Handley, Daniel; Kaplan, Tommy; Yu, Haiying; Bais, Abha S; Richards, Thomas; Pandit, Kusum V; Zeng, Qilu; Benos, Panayiotis V; Friedman, Nir; Eickelberg, Oliver; Kaminski, Naftali
- Abstract
Transforming growth factor beta 1 (TGFβ1) plays a major role in many lung diseases including lung cancer, pulmonary hypertension, and pulmonary fibrosis. TGFβ1 activates a signal transduction cascade that results in the transcriptional regulation of genes in the nucleus, primarily through the DNA-binding transcription factor SMAD3. The objective of this study is to identify genome-wide scale map of SMAD3 binding targets and the molecular pathways and networks affected by the TGFβ1/SMAD3 signaling in lung epithelial cells.
- Publication
PloS one, 2011, Vol 6, Issue 5, pe20319
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0020319