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- Title
Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm.
- Authors
Pacheco, Sara E; Houseman, E Andres; Christensen, Brock C; Marsit, Carmen J; Kelsey, Karl T; Sigman, Mark; Boekelheide, Kim
- Abstract
In previous studies using candidate gene approaches, low sperm count (oligospermia) has been associated with altered sperm mRNA content and DNA methylation in both imprinted and non-imprinted genes. We performed a genome-wide analysis of sperm DNA methylation and mRNA content to test for associations with sperm function.
- Publication
PloS one, 2011, Vol 6, Issue 6, pe20280
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0020280