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- Title
Seroconverting blood donors as a resource for characterising and optimising recent infection testing algorithms for incidence estimation.
- Authors
Kassanjee, Reshma; Welte, Alex; McWalter, Thomas A; Keating, Sheila M; Vermeulen, Marion; Stramer, Susan L; Busch, Michael P
- Abstract
Biomarker-based cross-sectional incidence estimation requires a Recent Infection Testing Algorithm (RITA) with an adequately large mean recency duration, to achieve reasonable survey counts, and a low false-recent rate, to minimise exposure to further bias and imprecision. Estimating these characteristics requires specimens from individuals with well-known seroconversion dates or confirmed long-standing infection. Specimens with well-known seroconversion dates are typically rare and precious, presenting a bottleneck in the development of RITAs.
- Publication
PloS one, 2011, Vol 6, Issue 6, pe20027
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0020027