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- Title
Cell-intrinsic NF-κB activation is critical for the development of natural regulatory T cells in mice.
- Authors
Gückel, Eva; Frey, Silke; Zaiss, Mario M; Schett, Georg; Ghosh, Sankar; Voll, Reinhard E
- Abstract
Naturally occurring CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells develop in the thymus and represent a mature T cell subpopulation critically involved in maintaining peripheral tolerance. The differentiation of Treg cells in the thymus requires T cell receptor (TCR)/CD28 stimulation along with cytokine-promoted Foxp3 induction. TCR-mediated nuclear factor kappa B (NF-κB) activation seems to be involved in differentiation of Treg cells because deletion of components of the NF-κB signaling pathway, as well as of NF-κB transcription factors, leads to markedly decreased Treg cell numbers in thymus and periphery.
- Publication
PloS one, 2011, Vol 6, Issue 5, pe20003
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0020003