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- Title
Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle.
- Authors
Masharani, Umesh B; Maddux, Betty A; Li, Xiaojuan; Sakkas, Giorgos K; Mulligan, Kathleen; Schambelan, Morris; Goldfine, Ira D; Youngren, Jack F
- Abstract
The pathogenesis of insulin resistance in the absence of obesity is unknown. In obesity, multiple stress kinases have been identified that impair the insulin signaling pathway via serine phosphorylation of key second messenger proteins. These stress kinases are activated through various mechanisms related to lipid oversupply locally in insulin target tissues and in various adipose depots.
- Publication
PloS one, 2011, Vol 6, Issue 5, pe19878
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0019878