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- Title
Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study.
- Authors
O'Donovan, Aoife; Pantell, Matthew S; Puterman, Eli; Dhabhar, Firdaus S; Blackburn, Elizabeth H; Yaffe, Kristine; Cawthon, Richard M; Opresko, Patricia L; Hsueh, Wen-Chi; Satterfield, Suzanne; Newman, Anne B; Ayonayon, Hilsa N; Rubin, Susan M; Harris, Tamara B; Epel, Elissa S; Health Aging and Body Composition Study
- Abstract
Leukocyte telomere length (LTL) is an emerging marker of biological age. Chronic inflammatory activity is commonly proposed as a promoter of biological aging in general, and of leukocyte telomere shortening in particular. In addition, senescent cells with critically short telomeres produce pro-inflammatory factors. However, in spite of the proposed causal links between inflammatory activity and LTL, there is little clinical evidence in support of their covariation and interaction.
- Publication
PloS one, 2011, Vol 6, Issue 5, pe19687
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0019687