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- Title
Elevated miR-499 levels blunt the cardiac stress response.
- Authors
Shieh, Joseph T C; Huang, Yu; Gilmore, Jacqueline; Srivastava, Deepak
- Abstract
The heart responds to myriad stresses by well-described transcriptional responses that involve long-term changes in gene expression as well as more immediate, transient adaptations. MicroRNAs quantitatively regulate mRNAs and thus may affect the cardiac transcriptional output and cardiac function. Here we investigate miR-499, a microRNA embedded within a ventricular-specific myosin heavy chain gene, which is expressed in heart and skeletal muscle.
- Publication
PloS one, 2011, Vol 6, Issue 5, pe19481
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0019481