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- Title
Three-dimensional cryoEM reconstruction of native LDL particles to 16Å resolution at physiological body temperature.
- Authors
Kumar, Vibhor; Butcher, Sarah J; Öörni, Katariina; Engelhardt, Peter; Heikkonen, Jukka; Kaski, Kimmo; Ala-Korpela, Mika; Kovanen, Petri T
- Abstract
Low-density lipoprotein (LDL) particles, the major carriers of cholesterol in the human circulation, have a key role in cholesterol physiology and in the development of atherosclerosis. The most prominent structural components in LDL are the core-forming cholesteryl esters (CE) and the particle-encircling single copy of a huge, non-exchangeable protein, the apolipoprotein B-100 (apoB-100). The shape of native LDL particles and the conformation of native apoB-100 on the particles remain incompletely characterized at the physiological human body temperature (37 °C).
- Publication
PloS one, 2011, Vol 6, Issue 5, pe18841
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0018841