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- Title
Association of HIV diversity and survival in HIV-infected Ugandan infants.
- Authors
James, Maria M; Wang, Lei; Musoke, Philippa; Donnell, Deborah; Fogel, Jessica; Towler, William I; Khaki, Leila; Nakabiito, Clemensia; Jackson, J Brooks; Eshleman, Susan H
- Abstract
The level of viral diversity in an HIV-infected individual can change during the course of HIV infection, reflecting mutagenesis during viral replication and selection of viral variants by immune and other selective pressures. Differences in the level of viral diversity in HIV-infected infants may reflect differences in viral dynamics, immune responses, or other factors that may also influence HIV disease progression. We used a novel high resolution melting (HRM) assay to measure HIV diversity in Ugandan infants and examined the relationship between diversity and survival through 5 years of age.
- Publication
PloS one, 2011, Vol 6, Issue 4, pe18642
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0018642