We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Differential glucose-regulation of microRNAs in pancreatic islets of non-obese type 2 diabetes model Goto-Kakizaki rat.
- Authors
Esguerra, Jonathan Lou S; Bolmeson, Caroline; Cilio, Corrado M; Eliasson, Lena
- Abstract
The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of the GK rats and investigate both their short- and long term glucose-dependence during glucose-stimulatory conditions.
- Publication
PloS one, 2011, Vol 6, Issue 4, pe18613
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0018613