We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reversal of diabetic nephropathy by a ketogenic diet.
- Authors
Poplawski, Michal M; Mastaitis, Jason W; Isoda, Fumiko; Grosjean, Fabrizio; Zheng, Feng; Mobbs, Charles V
- Abstract
Intensive insulin therapy and protein restriction delay the development of nephropathy in a variety of conditions, but few interventions are known to reverse nephropathy. Having recently observed that the ketone 3-beta-hydroxybutyric acid (3-OHB) reduces molecular responses to glucose, we hypothesized that a ketogenic diet, which produces prolonged elevation of 3-OHB, may reverse pathological processes caused by diabetes. To address this hypothesis, we assessed if prolonged maintenance on a ketogenic diet would reverse nephropathy produced by diabetes. In mouse models for both Type 1 (Akita) and Type 2 (db/db) diabetes, diabetic nephropathy (as indicated by albuminuria) was allowed to develop, then half the mice were switched to a ketogenic diet. After 8 weeks on the diet, mice were sacrificed to assess gene expression and histology. Diabetic nephropathy, as indicated by albumin/creatinine ratios as well as expression of stress-induced genes, was completely reversed by 2 months maintenance on a ketogenic diet. However, histological evidence of nephropathy was only partly reversed. These studies demonstrate that diabetic nephropathy can be reversed by a relatively simple dietary intervention. Whether reduced glucose metabolism mediates the protective effects of the ketogenic diet remains to be determined.
- Publication
PloS one, 2011, Vol 6, Issue 4, pe18604
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0018604