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- Title
R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes.
- Authors
Santosuosso, Michael; Righi, Elda; Hill, E David; Leblanc, Pierre R; Kodish, Brett; Mylvaganam, Hari N; Siddappa, Nagadenahalli B; Stevceva, Liljana; Hu, Shiu-Lok; Ghebremichael, Musie; Chenine, Agnes-L; Hovav, Avi-Hai; Ruprecht, Ruth M; Poznansky, Mark C
- Abstract
HIV-1 is a pathogen that T cell responses fail to control. HIV-1gp120 is the surface viral envelope glycoprotein that interacts with CD4 T cells and mediates entry. HIV-1gp120 has been implicated in immune dysregulatory functions that may limit anti-HIV antigen-specific T cell responses. We hypothesized that in the context of early SHIV infection, immune dysregulation of antigen-specific T-effector cell and regulatory functions would be detectable and that these would be associated or correlated with measurable concentrations of HIV-1gp120 in lymphoid tissues.
- Publication
PloS one, 2011, Vol 6, Issue 4, pe18465
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0018465