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- Title
Functional role of kallikrein 6 in regulating immune cell survival.
- Authors
Scarisbrick, Isobel A; Epstein, Benjamin; Cloud, Beth A; Yoon, Hyesook; Wu, Jianmin; Renner, Danielle N; Blaber, Sachiko I; Blaber, Michael; Vandell, Alexander G; Bryson, Alexandra L
- Abstract
Kallikrein 6 (KLK6) is a newly identified member of the kallikrein family of secreted serine proteases that prior studies indicate is elevated at sites of central nervous system (CNS) inflammation and which shows regulated expression with T cell activation. Notably, KLK6 is also elevated in the serum of multiple sclerosis (MS) patients however its potential roles in immune function are unknown. Herein we specifically examine whether KLK6 alters immune cell survival and the possible mechanism by which this may occur.
- Publication
PloS one, 2011, Vol 6, Issue 3, pe18376
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0018376