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- Title
Bioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitors.
- Authors
Knauer, Shirley K; Fetz, Verena; Rabenstein, Jens; Friedl, Sandra; Hofmann, Bettina; Sabiani, Samaneh; Schröder, Elisabeth; Kunst, Lena; Proschak, Eugen; Thines, Eckhard; Kindler, Thomas; Schneider, Gisbert; Marschalek, Rolf; Stauber, Roland H; Bier, Carolin
- Abstract
Threonine Aspartase 1 (Taspase1) mediates cleavage of the mixed lineage leukemia (MLL) protein and leukemia provoking MLL-fusions. In contrast to other proteases, the understanding of Taspase1's (patho)biological relevance and function is limited, since neither small molecule inhibitors nor cell based functional assays for Taspase1 are currently available.
- Publication
PloS one, 2011, Vol 6, Issue 5, pe18253
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0018253