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- Title
Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria.
- Authors
Fiamegos, Yiannis C; Kastritis, Panagiotis L; Exarchou, Vassiliki; Han, Haley; Bonvin, Alexandre M J J; Vervoort, Jacques; Lewis, Kim; Hamblin, Michael R; Tegos, George P
- Abstract
Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated as potential alternative treatments. One plausible antimicrobial alternative could be the combination of conventional antimicrobial agents/antibiotics with small molecules which block multidrug efflux systems known as efflux pump inhibitors. Bioassay-driven purification and structural determination of compounds from plant sources have yielded a number of pump inhibitors which acted against gram positive bacteria.
- Publication
PloS one, 2011, Vol 6, Issue 4, pe18127
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0018127