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- Title
Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings.
- Authors
Wolkowitz, Owen M; Mellon, Synthia H; Epel, Elissa S; Lin, Jue; Dhabhar, Firdaus S; Su, Yali; Reus, Victor I; Rosser, Rebecca; Burke, Heather M; Kupferman, Eve; Compagnone, Mariana; Nelson, J Craig; Blackburn, Elizabeth H
- Abstract
Depression is associated with an unusually high rate of aging-related illnesses and early mortality. One aspect of "accelerated aging" in depression may be shortened leukocyte telomeres. When telomeres critically shorten, as often occurs with repeated mitoses or in response to oxidation and inflammation, cells may die. Indeed, leukocyte telomere shortening predicts early mortality and medical illnesses in non-depressed populations. We sought to determine if leukocyte telomeres are shortened in Major Depressive Disorder (MDD), whether this is a function of lifetime depression exposure and whether this is related to putative mediators, oxidation and inflammation.
- Publication
PloS one, 2011, Vol 6, Issue 3, pe17837
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0017837