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- Title
Genomic signatures of strain selection and enhancement in Bacillus atrophaeus var. globigii, a historical biowarfare simulant.
- Authors
Gibbons, Henry S; Broomall, Stacey M; McNew, Lauren A; Daligault, Hajnalka; Chapman, Carol; Bruce, David; Karavis, Mark; Krepps, Michael; McGregor, Paul A; Hong, Charles; Park, Kyong H; Akmal, Arya; Feldman, Andrew; Lin, Jeffrey S; Chang, Wenling E; Higgs, Brandon W; Demirev, Plamen; Lindquist, John; Liem, Alvin; Fochler, Ed; Read, Timothy D; Tapia, Roxanne; Johnson, Shannon; Bishop-Lilly, Kimberly A; Detter, Chris; Han, Cliff; Sozhamannan, Shanmuga; Rosenzweig, C Nicole; Skowronski, Evan W
- Abstract
Despite the decades-long use of Bacillus atrophaeus var. globigii (BG) as a simulant for biological warfare (BW) agents, knowledge of its genome composition is limited. Furthermore, the ability to differentiate signatures of deliberate adaptation and selection from natural variation is lacking for most bacterial agents. We characterized a lineage of BGwith a long history of use as a simulant for BW operations, focusing on classical bacteriological markers, metabolic profiling and whole-genome shotgun sequencing (WGS).
- Publication
PloS one, 2011, Vol 6, Issue 3, pe17836
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0017836