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- Title
Vulnerability of polarised intestinal porcine epithelial cells to mycotoxin deoxynivalenol depends on the route of application.
- Authors
Diesing, Anne-Kathrin; Nossol, Constanze; Dänicke, Sven; Walk, Nicole; Post, Andreas; Kahlert, Stefan; Rothkötter, Hermann-Josef; Kluess, Jeannette
- Abstract
Deoxynivalenol (DON) is a Fusarium derived mycotoxin, often occurring on cereals used for human and animal nutrition. The intestine, as prominent barrier for nutritional toxins, has to handle the mycotoxin from the mucosa protected luminal side (apical exposure), as well as already absorbed toxin, reaching the cells from basolateral side via the blood stream. In the present study, the impact of the direction of DON exposure on epithelial cell behaviour and intestinal barrier integrity was elucidated.
- Publication
PloS one, 2011, Vol 6, Issue 2, pe17472
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0017472