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- Title
Brown adipose tissue in morbidly obese subjects.
- Authors
Vijgen, Guy H E J; Bouvy, Nicole D; Teule, G J Jaap; Brans, Boudewijn; Schrauwen, Patrick; van Marken Lichtenbelt, Wouter D
- Abstract
Cold-stimulated adaptive thermogenesis in brown adipose tissue (BAT) to increase energy expenditure is suggested as a possible therapeutic target for the treatment of obesity. We have recently shown high prevalence of BAT in adult humans, which was inversely related to body mass index (BMI) and body fat percentage (BF%), suggesting that obesity is associated with lower BAT activity. Here, we examined BAT activity in morbidly obese subjects and its role in cold-induced thermogenesis (CIT) after applying a personalized cooling protocol. We hypothesize that morbidly obese subjects show reduced BAT activity upon cold exposure.
- Publication
PloS one, 2011, Vol 6, Issue 2, pe17247
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0017247