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- Title
An unexpected role for the clock protein timeless in developmental apoptosis.
- Authors
O'Reilly, Linda P; Watkins, Simon C; Smithgall, Thomas E
- Abstract
Programmed cell death is critical not only in adult tissue homeostasis but for embryogenesis as well. One of the earliest steps in development, formation of the proamniotic cavity, involves coordinated apoptosis of embryonic cells. Recent work from our group demonstrated that c-Src protein-tyrosine kinase activity triggers differentiation of mouse embryonic stem (mES) cells to primitive ectoderm-like cells. In this report, we identified Timeless (Tim), the mammalian ortholog of a Drosophila circadian rhythm protein, as a binding partner and substrate for c-Src and probed its role in the differentiation of mES cells.
- Publication
PloS one, 2011, Vol 6, Issue 2, pe17157
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0017157