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- Title
Human stiff-person syndrome IgG induces anxious behavior in rats.
- Authors
Geis, Christian; Weishaupt, Andreas; Grünewald, Benedikt; Wultsch, Thomas; Reif, Andreas; Gerlach, Manfred; Dirkx, Ron; Solimena, Michele; Perani, Daniela; Heckmann, Manfred; Toyka, Klaus V; Folli, Franco; Sommer, Claudia
- Abstract
Anxiety is a heterogeneous behavioral domain playing a role in a variety of neuropsychiatric diseases. While anxiety is the cardinal symptom in disorders such as panic disorder, co-morbid anxious behavior can occur in a variety of diseases. Stiff person syndrome (SPS) is a CNS disorder characterized by increased muscle tone and prominent agoraphobia and anxiety. Most patients have high-titer antibodies against glutamate decarboxylase (GAD) 65. The pathogenic role of these autoantibodies is unclear.
- Publication
PloS one, 2011, Vol 6, Issue 2, pe16775
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0016775