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- Title
Cell cycle control and DNA damage response of conditionally immortalized urothelial cells.
- Authors
Dixon, Bradley P; Henry, Jeff; Siroky, Brian J; Chu, Albert; Groen, Pamela A; Bissler, John J
- Abstract
Children with complex urogenital anomalies often require bladder reconstruction. Gastrointestinal tissues used in bladder augmentations exhibit a greatly increased risk of malignancy, and the bladder microenvironment may play a role in this carcinogenesis. Investigating the influences of the bladder microenvironment on gastrointestinal and urothelial cell cycle checkpoint activation and DNA damage response has been limited by the lack of an appropriate well-differentiated urothelial cell line system.
- Publication
PloS one, 2011, Vol 6, Issue 1, pe16595
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0016595