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- Title
Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1.
- Authors
Mattiuzzo, Marta; Vargiu, Giulia; Totta, Pierangela; Fiore, Mario; Ciferri, Claudio; Musacchio, Andrea; Degrassi, Francesca
- Abstract
Highly Expressed in Cancer protein 1 (Hec1) is a constituent of the Ndc80 complex, a kinetochore component that has been shown to have a fundamental role in stable kinetochore-microtubule attachment, chromosome alignment and spindle checkpoint activation at mitosis. HEC1 RNA is found up-regulated in several cancer cells, suggesting a role for HEC1 deregulation in cancer. In light of this, we have investigated the consequences of experimentally-driven Hec1 expression on mitosis and chromosome segregation in an inducible expression system from human cells.
- Publication
PloS one, 2011, Vol 6, Issue 1, pe16307
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0016307