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- Title
Vectors based on modified vaccinia Ankara expressing influenza H5N1 hemagglutinin induce substantial cross-clade protective immunity.
- Authors
Hessel, Annett; Schwendinger, Michael; Holzer, Georg W; Orlinger, Klaus K; Coulibaly, Sogue; Savidis-Dacho, Helga; Zips, Marie-Luise; Crowe, Brian A; Kreil, Thomas R; Ehrlich, Hartmut J; Barrett, P Noel; Falkner, Falko G
- Abstract
New highly pathogenic H5N1 influenza viruses are continuing to evolve with a potential threat for an influenza pandemic. So far, the H5N1 influenza viruses have not widely circulated in humans and therefore constitute a high risk for the non immune population. The aim of this study was to evaluate the cross-protective potential of the hemagglutinins of five H5N1 strains of divergent clades using a live attenuated modified vaccinia Ankara (MVA) vector vaccine.
- Publication
PloS one, 2011, Vol 6, Issue 1, pe16247
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0016247