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- Title
Role of intestinal bacteria in gliadin-induced changes in intestinal mucosa: study in germ-free rats.
- Authors
Cinova, Jana; De Palma, Giada; Stepankova, Renata; Kofronova, Olga; Kverka, Miloslav; Sanz, Yolanda; Tuckova, Ludmila
- Abstract
Celiac disease (CD) is a chronic inflammatory disorder of the small intestine that is induced by dietary wheat gluten proteins (gliadins) in genetically predisposed individuals. The overgrowth of potentially pathogenic bacteria and infections has been suggested to contribute to CD pathogenesis. We aimed to study the effects of gliadin and various intestinal bacterial strains on mucosal barrier integrity, gliadin translocation, and cytokine production.
- Publication
PloS one, 2011, Vol 6, Issue 1, pe16169
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0016169