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- Title
S-adenosyl-methionine and betaine improve early virological response in chronic hepatitis C patients with previous nonresponse.
- Authors
Filipowicz, Magdalena; Bernsmeier, Christine; Terracciano, Luigi; Duong, Francois H T; Heim, Markus H
- Abstract
Treatment of chronic hepatitis C (CHC) with pegylated interferon α (pegIFNα) and ribavirin results in a sustained response in approximately half of patients. Viral interference with IFNα signal transduction through the Jak-STAT pathway might be an important factor underlying treatment failure. S-adenosyl-L-methionine (SAMe) and betaine potentiate IFNα signaling in cultured cells that express hepatitis C virus (HCV) proteins, and enhance the inhibitory effect of IFNα on HCV replicons. We have performed a clinical study with the aim to evaluate efficacy and safety of the addition of SAMe and betaine to treatment of CHC with pegIFNα/ribavirin.
- Publication
PloS one, 2010, Vol 5, Issue 11, pe15492
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0015492