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- Title
The Prevalence and Regulation of Antisense Transcripts in Schizosaccharomyces pombe.
- Authors
Ting Ni; Kang Tu; Zhong Wang; Shen Song; Han Wu; Bin Xie; Scott, Kristin C.; Grewal, Shiv I.; Yuan Gao; Jun Zhu
- Abstract
A strand-specific transcriptome sequencing strategy, directional ligation sequencing or DeLi-seq, was employed to profile antisense transcriptome of Schizosaccharomyces pombe. Under both normal and heat shock conditions, we found that polyadenylated antisense transcripts are broadly expressed while distinct expression patterns were observed for proteincoding and non-coding loci. Dominant antisense expression is enriched in protein-coding genes involved in meiosis or stress response pathways. Detailed analyses further suggest that antisense transcripts are independently regulated with respect to their sense transcripts, and diverse mechanisms might be potentially involved in the biogenesis and degradation of antisense RNAs. Taken together, antisense transcription may have profound impacts on global gene regulation in S. pombe.
- Publication
PLoS ONE, 2010, Vol 5, Issue 12, p1
- ISSN
1932-6203
- Publication type
Academic Journal
- DOI
10.1371/journal.pone.0015271