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- Title
Involvement of 5-lipoxygenase in the corticosteroid-dependent amyloid beta formation: in vitro and in vivo evidence.
- Authors
Puccio, Simone; Chu, Jin; Praticò, Domenico
- Abstract
Numerous studies show that high circulating level of glucocorticosteroids is a biochemical characteristic of Alzheimer's disease (AD). These stress hormones can increase the amount of AD-like pathology in animal models of the disease. Since they also up-regulate the 5-Lipoxygenase (5-LO), an enzyme which modulates amyloid beta (Aβ) formation, in the present paper we tested the hypothesis that this enzymatic pathway is involved in the glucocorticoid-induced pro-amyloidotic effect.
- Publication
PloS one, 2011, Vol 6, Issue 1, pe15163
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0015163