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- Title
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer.
- Authors
Ostroff, Rachel M; Bigbee, William L; Franklin, Wilbur; Gold, Larry; Mehan, Mike; Miller, York E; Pass, Harvey I; Rom, William N; Siegfried, Jill M; Stewart, Alex; Walker, Jeffrey J; Weissfeld, Joel L; Williams, Stephen; Zichi, Dom; Brody, Edward N
- Abstract
Lung cancer is the leading cause of cancer deaths worldwide. New diagnostics are needed to detect early stage lung cancer because it may be cured with surgery. However, most cases are diagnosed too late for curative surgery. Here we present a comprehensive clinical biomarker study of lung cancer and the first large-scale clinical application of a new aptamer-based proteomic technology to discover blood protein biomarkers in disease.
- Publication
PloS one, 2010, Vol 5, Issue 12, pe15003
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0015003