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- Title
Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers.
- Authors
Madsen, Karina M; Udatha, Gupta D B R K; Semba, Saori; Otero, Jose M; Koetter, Peter; Nielsen, Jens; Ebizuka, Yutaka; Kushiro, Tetsuo; Panagiotou, Gianni
- Abstract
Metabolic engineering is an attractive approach in order to improve the microbial production of drugs. Triterpenes is a chemically diverse class of compounds and many among them are of interest from a human health perspective. A systematic experimental or computational survey of all feasible gene modifications to determine the genotype yielding the optimal triterpene production phenotype is a laborious and time-consuming process.
- Publication
PloS one, 2011, Vol 6, Issue 3, pe14763
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0014763