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- Title
Exploitation of herpesvirus immune evasion strategies to modify the immunogenicity of human mesenchymal stem cell transplants.
- Authors
de la Garza-Rodea, Anabel S; Verweij, Marieke C; Boersma, Hester; van der Velde-van Dijke, Ietje; de Vries, Antoine A F; Hoeben, Rob C; van Bekkum, Dirk W; Wiertz, Emmanuel J H J; Knaän-Shanzer, Shoshan
- Abstract
Mesenchymal stem cells (MSCs) are multipotent cells residing in the connective tissue of many organs and holding great potential for tissue repair. In culture, human MSCs (hMSCs) are capable of extensive proliferation without showing chromosomal aberrations. Large numbers of hMSCs can thus be acquired from small samples of easily obtainable tissues like fat and bone marrow. MSCs can contribute to regeneration indirectly by secretion of cytokines or directly by differentiation into specialized cell types. The latter mechanism requires their long-term acceptance by the recipient. Although MSCs do not elicit immune responses in vitro, animal studies have revealed that allogeneic and xenogeneic MSCs are rejected.
- Publication
PloS one, 2011, Vol 6, Issue 1, pe14493
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0014493