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- Title
Zebrafish numb and numblike are involved in primitive erythrocyte differentiation.
- Authors
Bresciani, Erica; Confalonieri, Stefano; Cermenati, Solei; Cimbro, Simona; Foglia, Efrem; Beltrame, Monica; Di Fiore, Pier Paolo; Cotelli, Franco
- Abstract
Notch signaling is an evolutionarily conserved regulatory circuitry implicated in cell fate determination in various developmental processes including hematopoietic stem cell self-renewal and differentiation of blood lineages. Known endogenous inhibitors of Notch activity are Numb-Nb and Numblike-Nbl, which play partially redundant functions in specifying and maintaining neuronal differentiation. Nb and Nbl are expressed in most tissues including embryonic and adult hematopoietic tissues in mice and humans, suggesting possible roles for these proteins in hematopoiesis.
- Publication
PloS one, 2010, Vol 5, Issue 12, pe14296
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0014296