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- Title
Phenotypic characterization of transgenic mice overexpressing neuregulin-1.
- Authors
Kato, Taisuke; Kasai, Atsushi; Mizuno, Makoto; Fengyi, Liang; Shintani, Norihito; Maeda, Sadaaki; Yokoyama, Minesuke; Ozaki, Miwako; Nawa, Hiroyuki
- Abstract
Neuregulin-1 (NRG1) is one of the susceptibility genes for schizophrenia and implicated in the neurotrophic regulation of GABAergic and dopaminergic neurons, myelination, and NMDA receptor function. Postmortem studies often indicate a pathologic association of increased NRG1 expression or signaling with this illness. However, the psychobehavioral implication of NRG1 signaling has mainly been investigated using hypomorphic mutant mice for individual NRG1 splice variants.
- Publication
PloS one, 2010, Vol 5, Issue 12, pe14185
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0014185