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- Title
Phenotypic complexity, measurement bias, and poor phenotypic resolution contribute to the missing heritability problem in genetic association studies.
- Authors
van der Sluis, Sophie; Verhage, Matthijs; Posthuma, Danielle; Dolan, Conor V
- Abstract
The variance explained by genetic variants as identified in (genome-wide) genetic association studies is typically small compared to family-based heritability estimates. Explanations of this 'missing heritability' have been mainly genetic, such as genetic heterogeneity and complex (epi-)genetic mechanisms.
- Publication
PloS one, 2010, Vol 5, Issue 11, pe13929
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0013929