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- Title
Loss of 'small-world' networks in Alzheimer's disease: graph analysis of FMRI resting-state functional connectivity.
- Authors
Sanz-Arigita, Ernesto J; Schoonheim, Menno M; Damoiseaux, Jessica S; Rombouts, Serge A R B; Maris, Erik; Barkhof, Frederik; Scheltens, Philip; Stam, Cornelis J
- Abstract
Local network connectivity disruptions in Alzheimer's disease patients have been found using graph analysis in BOLD fMRI. Other studies using MEG and cortical thickness measures, however, show more global long distance connectivity changes, both in functional and structural imaging data. The form and role of functional connectivity changes thus remains ambiguous. The current study shows more conclusive data on connectivity changes in early AD using graph analysis on resting-state condition fMRI data.
- Publication
PloS one, 2010, Vol 5, Issue 11, pe13788
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0013788