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- Title
Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype.
- Authors
Lewis-Tuffin, Laura J; Rodriguez, Fausto; Giannini, Caterina; Scheithauer, Bernd; Necela, Brian M; Sarkaria, Jann N; Anastasiadis, Panos Z
- Abstract
Cadherins are essential components of the adherens junction complexes that mediate cell-cell adhesion and regulate cell motility. During tissue morphogenesis, changes in cadherin expression (known as cadherin switching) are a common mechanism for altering cell fate. Cadherin switching is also common during epithelial tumor progression, where it is thought to promote tumor invasion and metastasis. E-cadherin is the predominant cadherin expressed in epithelial tissues, but its expression is very limited in normal brain.
- Publication
PloS one, 2010, Vol 5, Issue 10, pe13665
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0013665