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- Title
Bypass mechanisms of the androgen receptor pathway in therapy-resistant prostate cancer cell models.
- Authors
Marques, Rute B; Dits, Natasja F; Erkens-Schulze, Sigrun; van Weerden, Wytske M; Jenster, Guido
- Abstract
Prostate cancer is initially dependent on androgens for survival and growth, making hormonal therapy the cornerstone treatment for late-stage tumors. However, despite initial remission, the cancer will inevitably recur. The present study was designed to investigate how androgen-dependent prostate cancer cells eventually survive and resume growth under androgen-deprived and antiandrogen supplemented conditions. As model system, we used the androgen-responsive PC346C cell line and its therapy-resistant sublines: PC346DCC, PC346Flu1 and PC346Flu2.
- Publication
PloS one, 2010, Vol 5, Issue 10, pe13500
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0013500