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- Title
Reduced satellite cell numbers and myogenic capacity in aging can be alleviated by endurance exercise.
- Authors
Shefer, Gabi; Rauner, Gat; Yablonka-Reuveni, Zipora; Benayahu, Dafna
- Abstract
Muscle regeneration depends on satellite cells, myogenic stem cells that reside on the myofiber surface. Reduced numbers and/or decreased myogenic aptitude of these cells may impede proper maintenance and contribute to the age-associated decline in muscle mass and repair capacity. Endurance exercise was shown to improve muscle performance; however, the direct impact on satellite cells in aging was not yet thoroughly determined. Here, we focused on characterizing the effect of moderate-intensity endurance exercise on satellite cell, as possible means to attenuate adverse effects of aging. Young and old rats of both genders underwent 13 weeks of treadmill-running or remained sedentary.
- Publication
PloS one, 2010, Vol 5, Issue 10, pe13307
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0013307