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- Title
MicroRNA-200 family members differentially regulate morphological plasticity and mode of melanoma cell invasion.
- Authors
Elson-Schwab, Ilan; Lorentzen, Anna; Marshall, Christopher J
- Abstract
A functional role of microRNAs (miRNAs or miRs) in neoplasia and metastasis is becoming clear, and the miR-200 family has received much attention for potentially regulating tumor progression. The miRNAs of this family have been shown to suppress epithelial-mesenchymal transition, and their down-regulation in some tumors promotes invasion and metastasis. Interestingly, while miR-200 is down-regulated in some cancers, it is up-regulated in others.
- Publication
PloS one, 2010, Vol 5, Issue 10
- ISSN
1932-6203
- Publication type
Journal Article
- DOI
10.1371/journal.pone.0013176